[Comment] The genetic architecture of dementia with Lewy bodies is shaping up
Genome-wide association studies (GWAS) have made substantial contributions to our understanding of complex neurodegenerative diseases. For example, the largest GWAS of Alzheimer's disease so far has identified 19 loci in addition to APOE and revealed key pathways of disease pathogenesis, including inflammation and immune response, lipid metabolism, and endocytosis.1 Similarly, two GWAS of Parkinson's disease have uncovered 41 loci and suggested a major role of autophagy and lysosomal biology in Parkinson's disease risk.
Ander nieuws
[Comment] A new step towards targeting tau
Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...
[Review] CSF and blood biomarkers for Parkinson’s disease
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...
Parkinson’s disease patient: ‘I can walk… it’s really helped me’
Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...